Tristan Knowles is fighting one of life’s toughest battles with a spirit that defies his years. Despite not being able to finish school and experiencing severely low oxygen levels, this teenager is facing each day with courage and hopes to secure funds for a miraculous treatment that could be a lifeline to the future he truly deserves.
South Africa (28 July 2025) – Some of life’s toughest battles are given to the strongest among us, though it may rarely feel that way in the moment. Inspiringly brave warrior, 18-year-old Tristan Knowles, has spent more time in the hospital than any teenager should.
Diagnosed with cystic fibrosis at the age of 12, Tristan has faced a cruel, progressive disease with tremendous courage and spirit.
His entire family has walked every step of this difficult journey with him, and after being told what no parent should ever have to hear from doctors, they did their research and discovered Trikafta, a breakthrough treatment that could change the course of Tristan’s life.
Having already lost two family members to CF, the Knowles family has experienced firsthand the devastating impact of this illness. The treatment is said to target the root cause of the disease, and for many, it has meant better lung function, fewer hospital stays, and years of extended life.
“We have had to rethink everything we do and socialise,” shares Tristan’s mom, Vicky.
“We don’t go out a lot because it is safer for Tristan. Being exposed to certain bacteria and viruses can make him very sick. Last year was his final year of school, but he could not finish. His oxygen levels have gone down drastically, and he has had to be on oxygen permanently.”
Vicky bravely shares the emotional toll:
“Living with the thought of burying your child before you die is an emotional battle that you fight every day. Some days are easier than others, every birthday is such a milestone.”
The path to getting him the fixed-dose combination medication comes with a daunting financial hurdle. Although a new medical aid will eventually cover the cost, there’s a two-year waiting period.
In the meantime, out-of-pocket expenses total over R400,000, a figure far beyond what Tristan’s parents, Mathew and Vicky, can afford, especially while managing his current high-cost care.
A fundraising campaign has been launched through Breathtaking NPC, a non-profit organisation dedicated to raising awareness, supporting families, and funding treatment for individuals living with cystic fibrosis in South Africa.
This campaign aims to bridge the financial gap and give Tristan a fighting chance.
Described as a funny and artistic young man, the treatment will help Tristan get back to immersing himself in the things he loves, like art, cars and hopefully even further his studies.
The family appeals for support and donations in hopes of restoring Tristan’s health and getting him back on track to living the life he so deeply deserves.
To support Tristan’s journey, visit the fundraising campaign here.
Sources: Supplied
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